Prevalence, awareness, treatment and control of hypertension in a nigerian population

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Prevalence, awareness, treatment and control of hypertension in a nigerian population
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  Vol.2, No.7, 731-735 (2010)   doi:10.4236/health.2010.27111 Copyright © 2010 SciRes. Openly accessible at http://www.scirp.org/journal/HEALTH/ Health   Prevalence, awareness, treatment and control of hypertension in a nigerian population Obinna Ikechukwu Ekwunife*, Patrick Obinna Udeogaranya, Izuchukwu Loveth Nwatu Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria Nsukka; Department of Pharmacy, Enugu State Teaching Hospital Enugu State, Nigeria; * Corresponding Author: obinna.ekwunife@unn.edu.ng Received 19 January 2010; revised 24 March 2010; accepted 26 March 2010. ABSTRACT   Hypertension is a major public health problem. Due to paucity of data, the burden of hyperten-sion in Nigeria might be underestimated. Esti-mating the prevalence of hypertension in popu- lations of Nigeria would be useful in efforts to control hypertension and prevent its conse-quences. This survey aimed to assess the pr- evalence, detection, treatment and control of hypertension in Nsukka, a city located in South- Eastern Nigeria. Hypertension prevalence, awa- reness, treatment, and control   (outcomes) were examined in   756 adult participants (364 men and 392 women) aged 18 years and above. Blood pressure (BP) of the participants was measured and they also answered a detailed questionnaire. Hypertension was defined as BP ≥  140 for sys-tolic BP and or ≥  90 mm Hg for diastolic BP or being on antihypertensive therapy. Prevalence of hypertension was 21.1%. Men had higher prevalence of high BP compared to women. Systolic and diastolic BP increased with age in both men and women. Detection of high BP in participants with raised blood pressure was 40.3% and 24.7% for males and females respec-tively. Only 23.7% and 17.5% of males and fe-males respectively with high BP were on anti-hypertensive treatment while 5.0% of males and 17.5% of females with hypertension were con-trolled. Prevalence of hypertension was com-parable with other studies in Nigeria and Africa. The results showed a poor detection, treatment and control of hypertension. This underscores the need for comprehensive evaluation of the prevalence of hypertension and other cardio-vascular diseases in Nigeria. Keywords:   Hypertension; Prevalence; Epidemiology; Nsukka   1. INTRODUCTION Hypertension is a major public health problem. World-wide, prevalence estimates for hypertension is about 1  billion individuals [1]. It causes about 7.1 million deaths  per year [2]   and 4.5% of the disease burden which trans-lates to 64 million disability adjusted life years (DALYs) [3]. The relationship between blood pressure (BP) and risk of cardiovascular diseases events is continuous, consistent, and independent of other risk factors. The higher the BP, the greater is the chance of heart attack, heart failure, stroke, and kidney diseases [4]. The burden of non-communicable diseases (NCDs) such as hypertension is increasing in epidemic propor-tions in Africa. According to the World Health Report 2001 ,  NCDs accounted for 22% of the total deaths in the region in the year 2000; cardiovascular diseases alone accounted for 9.2% of the total deaths, killing even more than malaria [2]. Major target-organ complications of hypertension, such as left ventricular hypertrophy [5], diastolic dysfunction [6], congestive heart failure [7], ischemic heart disease [8], stroke [9], and renal failure [10] have been established by various researchers in Ni-geria. Reducing the prevalence of hypertension would de-crease mortality and disability in middle-aged and older  persons and lead to a better quality of life. Reduction of hypertension prevalence could be achieved through risk factor prevention programmes as well as using low-cost management. However, in most countries of the African region, implementation of these approaches and pro-grammes is hampered by dearth of data on the preva-lence and control levels of hypertension. Scarcity of data is sometimes understood as non-existence of the prob-lem [3]. There is paucity of hypertension prevalence in many populations of Nigeria. Thus, burden of hyperten-sion in these populations might be underestimated and might leave the illness undiagnosed and untreated. Un-controlled hypertension clearly places a substantial strain on health care delivery system. Estimating the preva-    O. I. Ekwunife et al.  / HEALTH 2 (2010) 731-735   Copyright © 2010 SciRes. Openly accessible at http://www.scirp.org/journal/HEALTH/     732   lence of hypertension in populations of Nigeria would be useful in efforts to control hypertension and other NCDs. This survey aimed to assess the prevalence, detection, treatment and control of hypertension in Nsukka, a city located in South-Eastern Nigeria. 2. METHOD 2.1. Study Design and Population This is a household survey with the objective of assess-ing prevalence, awareness and control of hypertension in  Nsukka. Nsukka is a town located in South-Eastern Ni-geria and has an estimated population of 117,086. Chris-tianity is the main religion while farming, transportation and trading are the major commercial activities. The most prominent feature in Nsukka is the University of  Nigeria Nsukka, which attracts people of different ethnic and linguistic group to the area. There are 19 public health facilities and over 20 private health facilities in  Nsukka. 2.2. Ethical Consideration All procedures were carried out according to a study  protocol approved by the Local Ethics Committee of University of Nigeria Teaching Hospital Enugu. Objec-tives and nature of the study were explained to people that agreed to participate. Informed consent was orally obtained. The information about participant’s identity was not included with the other data and only the prin-cipal investigator had access to this information. No ref-erence to the participant’s identity was made at any stage during data analysis. 2.3. Sampling and Sample Size Calculation A mixture of cluster and systematic random technique was employed. Nsukka was grouped into 16 clusters  based on geographical locations as established by a map designed by Nsukka Graduates Association. Six sections or clusters were randomly selected from the sixteen clusters using a random sampling technique. In each section, the first house in each street was identified, fol-lowed by systematic sampling of the next three houses. Using “Statcalc” function of EPI INFO (Version 6, Cen-tre for Disease Control, USA), it was determined that a sample size of 400 was adequate to detect prevalence of hypertension of 10% to 40% with 5% precision and 95% confidence. However, a total of 800 persons were met in the exercise after covering the selected clusters. 2.4. BP Measurement and Interview Procedure The data collection tool was a questionnaire. The survey was carried out from April to August of 2009. Partici- pants that were included in the study were those from 18 years and above in each household identified. Those who took caffeine, smoked or did an exercise prior to the interview were excluded from the study. Participants were interviewed and blood pressure was measured at home. Data obtained were marital status, age, gender, educational status, estimated income per month, family history of hypertension, and co-morbidities. The inter-view was in English or in Igbo (the local dialect) for  participants that could not understand English. Blood  pressure was measured twice by the trained final year  pharmacy students using mercury sphygmomanometers and stethoscopes (Kris-Alloy®, Wuxi Medical Instru-ment Factory, Wuxi City Jiangsu, China). Blood pressure was measured after they were in resting state for 10 minutes and in sitting position in the right arm place at the level of the heart. An appropriate-sized cuff (cuff  bladder encircling at least 80% of the arm) was used to ensure accuracy [4]. High blood pressure was defined using the WHO/ISH criteria of SBP ≥  140 mmHg and/or DBP ≥  90 mmHg [11].   Prevalence of high BP was cal-culated as percentage of participants with SBP and DBP above WHO/ISH criteria, those that were known hyper-tensive and those on hypertension medication (s). Hy- pertension detection was defined as any prior diagnosis of hypertension made by a health professional among the  population defined as having hypertension. Treatment of hypertension was defined as use of recognized anti-hypertensive medication among the population defined as having hypertension, whereas control of hypertension was defined as blood pressure of < 140/90 mmHg among the population defined as having hypertension. 2.5. Data Analysis Mean levels of BP were reported by gender (male versus female) and age. Gender difference in blood pressure was conducted using 2-sample t-test while gender dif-ferences in detection, treatment and control rate was assessed using χ  2  test. All data analyses were conducted using SPSS 13.0 (Chicago, IL) software. Data were dou- ble checked by a staff of Clinical Pharmacy department, University of Nigeria Nsukka for consistency. A two- tailed significance level of 0.05 was used. 3. RESULTS A total of 800 participants were encountered in their homes but only 756 participants agreed to participate in the study (94.5% response rate). Majority of those that declined to participate were afraid to be diagnosed of hypertension and would not want their blood pressure measured. The rest did not want to participate because of time the exercise will take. Three hundred and sixty four  O. I. Ekwunife et al.  / HEALTH 2 (2010) 731-735   Copyright © 2010 SciRes. Openly accessible at http://www.scirp.org/journal/HEALTH/     733   733 (48.1%) were males while three hundred and ninety-two (51.9%) were females. Majority of the participants (about 60%) were married while the rest were single. Only a few of the participant (< 1%) were divorced. About 26% of the participants had a tertiary degree, 58% had up to secondary school training while 3% had no formal education. One half of the study population earned less than $ 100 in a month and men significantly earned more than women (T-test, p < 0.001). Details of the demographic characteristics of the study population are presented in Table 1 . Table 2  shows the details of clinical characteristics of the study population. Among the participants, 23.5% reported that they have a family history of hypertension. Mean systolic blood pressure in the study population was 129.8 ± 27.4 mmHg and mean diastolic blood pres-sure 85.1 ± 9.9 mmHg. Males had a significantly higher SBP compared to females –133.3 ± 14.3 mmHg vs 125.0 ± 14.6 mmHg respectively (T-test, p < 0.001). DBP was also significantly higher in males than in females –87.1 ± 9.3 mmHg vs 83.2 ± 10.2 mmHg respectively (T-test,  p < 0.001). Prevalence of high blood pressure was 21.1%. Systolic and diastolic BP increased with age as shown in Figure 1 . Detection of high BP in participants with raised blood Table 1. Demographic characteristics of the study population (n = 756). Variable Mean ± SD, frequencies (%) or median [Interquartile range] 1. Age (y) 34.9 ± 13.9 Gender  Male 364 (48.1) 2. Female 392 (51.9) Marital status Single 297 (38.4)  Married 458 (59.2) 3.  Divorced 6 (0.8) Educational status  No formal education 23 (3.0) Primary education 87 (11.2) Secondary education 450 (58.1) 4. Graduate 206 (26.1) 5. Average Individual Income ($/month) 83.3 [83.3 – 250] Table 2. Clinical characteristics of the study population. Variable Mean ± SD or percentages (%) 1. Family history of hypertension 23.5 2. Systolic blood pressure (mm Hg) 129.8 ± 27.4 3. Diastolic blood pressure (mm Hg) 85.1 ± 9.9 4. Prevalence of BP 21.1 Figure 1. Systolic and diastolic BP by age group in Nsukka urban, Nigeria. Results are shown as mean and standard devia-tion.  pressure was significantly higher in males (40.3%) compared to females (24.7%) ( χ  2 (1) = 4.2, p = 0.041). Overall detection rate was 30%. Percentage of partici- pants with high BP treated were 23.7% for males and 17.5% for males and females respectively. There was no significantly difference in treatment rate between men and women ( χ  2 (1) = 0.83, p = 0.36). On the total, 21% of participants with high BP take medications. On con-trol rate, 17.5% of the women were controlled while 5.0% of the men were controlled. There was significant gender difference in control rate ( χ  2 (1) = 6.73, p = 0.01). Overall control rate of BP amongst hypertensive was 9% in the study population. 4. DISCUSSION   This study presents the prevalence estimate of hypertension in Nsukka, an urban towngeria. in South-Eastern Ni   O. I. Ekwunife et al.  / HEALTH 2 (2010) 731-735   Copyright © 2010 SciRes. http://www.scirp.org/journal/HEALTH/Openly accessible at    734   Table 3. Blood pressure by age group and gender. Systolic BP (mm Hg) Diastolic BP (mm Hg)Systolic BP (mm Hg) Diastolic BP (mm Hg)Age group (y) n Men (n = 364) n Women (n = 392) ≤  19 28 123 ± 10 81 ± 8 31 118 ± 8 82 ± 8 20-29 106 127 ± 9 85 ± 8 162 119 ± 9 80 ± 8 30-39 75 132 ± 12 88 ± 9 109 127 ± 13 85 ± 9 40-49 85 136 ± 15 88 ± 8 48 128 ± 16 86 ± 12 50-59 36 143 ± 15 89 ± 6 18 136 ± 17 88 ± 9 ≥  60 34 147 ± 17 94 ± 14 24 145 ± 25 90 ± 19 Results are presented mean ± standard deviation Blood pressure showed a consistent increase with age in  both men and women. The survey showed that only 30% of persons with raised blood pressure were detected, 21% were detected, while 9% were controlled. Similar prevalence estimate have been documented in the literature. In South-Eastern Nigeria, prevalence of hypertension in a university community was as much as 21% [12]. Arterial hypertension was found in 25% of examined motor bike riders in Benin City, Nigeria [13]. It has been speculated that about 20%-25% Nigerian adults could be classed as hypertensive [14]. The consistent increase of blood pressure with age in  both men and women is a known occurrence and has  been reported elsewhere in Africa [15]. A recent study in  Nigeria (Kogi State) showed that blood pressures in-creased with age and body mass index [16]. The age- related rise in systolic blood pressure is primarily re-sponsible for an increase in both incidence and preva-lence of hypertension with age [17]. It has been stated that the prevalence of hypertension increases with ad-vancing age to the point where more than half of people aged 60 to 69 years old and approximately three-quarters of those aged 70 years and older are affected [1]. Though  blood pressure increased with age, men had a signifi-cantly higher blood pressure than women in all the age groups. The survey showed that only 30% of persons with raised blood pressure were detected, 21% were treated, while 9% were controlled. In general, our results showed a comparable level of detection, treatment and control of hypertension with those that have been reported in other surveys in Africa. For example in Ghana, it was reported that only 34% were aware that their blood pressure was high and 22.2% were taking antihypertensive medication,  but only 6.2% had optimal blood pressure control [18]. Although a recent survey in Nigeria by Omuemu et al ., reported a lower detection rate of 18.5% compared to 30% obtained in this survey, treatment and control rates in both surveys were comparable [19]. This study strengthens the fact that in sub-Saharan Af-rica, level of detection, treatment and control are still far less than results obtained in developed countries [20]. This poor level of detection, treatment and control has  been attributed to scarce resources and inadequate healthcare provision [21,22]. The poor level of detection, treatment and control of hypertension is a cause of con-cern. As hypertension is an important cardiovascular risk factor, many undetected hypertensive patients have a high risk of suffering from cardiovascular disease con-sequences such as myocardial infarction and stroke. As was stated earlier, the burden of hypertension might be underestimated in Nigeria. This study had some limitations. Stratified sampling technique would have been the best sampling method which will ensure the generalizability of the prevalence estimate. Also, since the blood pressure of the entire residents’ ( ≥  18 years) in the identified houses was measured, clustering effect could have resulted diluting the randomness of the sampling. 5. CONCLUSIONS   Prevalence of hypertension was comparable with other studies in Nigeria and Africa. Our results also showed a  poor detection, treatment and control of hypertension than has been reported in other surveys in Africa. This underscores the need for comprehensive evaluation of  prevalence of hypertension and other cardiovascular diseases in Nigeria. Information from this assessment could demonstrate the need to urgently address this emerging disease. It is also imperative to design cost- effective strategies which could be implemented to im- prove detection, adherence and control of hypertension in Nigeria.  O. I. Ekwunife et al.  / HEALTH 2 (2010) 731-735   Copyright © 2010 SciRes. Openly accessible at http://www.scirp.org/journal/HEALTH/     735   735 6. ACKNOWLEDGEMENTS   The authors wish to acknowledge the following final year pharmacy students that took part in the field study: Ejike Onah, Ifeanyi Aduaka, and Theresa Money. 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