Sickle Cell

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  Sickle Cell Disease  Sickle Cell Disease  Group of genetic disorders characterized by:  Hemolytic anemia -not enough red blood cells in the blood  Vasculopathy -disorder of blood vessels  In US, predominantly with African-Americans (i.e., 1 in 400)   Also occurs in descendents of Mediterranean, Indian, Asian, and Caribbean cultures  Sickle Cell Syndromes  Sickle Cell Trait (HbS gene)  Sickle Cell Anemia (HbS/HbS)  Hgb SC Disease  Sickle Beta-Thalassemia  SCA: Impact on Red Blood Cells  With low oxygen levels, the shape of red cells becomes distorted  They appear elongated and sickle shaped  Red blood cells become very fragile, short lived, and can clog blood vessels
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